BD Alaris™ PK Plus 注射泵 MK4 取扱説明書

s

Alaris™ PK Plus

MK4

8005TIG03

zh

BDDF00069 4

1/56

Alaris™ PK Plus

............................................................................................................ 2

..................................................................................................... 3

TCI ........................................................................................................ 4

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RS232 ............................................................ 48

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TCI ..................................................................................................51

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BDDF00069 4

2/56

Alaris™ PK Plus

Alaris™ PK Plus MK4

w

MK4 MK4

3.4.x

Alaris PK Plus

4

1. /

2. (TIVA)

–

3. TCI (TIVA)

–

4. TCI

• (TCI)

–

• (TCI)

–

Alaris PK Plus

/

Alaris PK Plus

Alaris PK Plus Alaris PK Plus

(DFU)

TCI

/

BD - - TCI

- Alaris PK Plus

TCI

(ASTRA-ZENECA) TCI Marsh

TCI Minto Gepts

w

BD

BDDF00069 4

3/56

Alaris™ PK Plus

Alaris PK Plus

•

Alaris PK Plus

1.0 / 5.0 /

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BD bd.com

BD

Battery Indicator

PURGEON/OFF/

w

BDDF00069 4

4/56

Alaris™ PK Plus

TCI

-

1/

1

Kruger-Thiemer

2

Schwilden

3

80 90 TCI

(V1) (V2)

(V3)k

12

k

21

k

31

k

13

k

10

2

TCI

cl2

k

12

k

21

k

31

k

10

k

13

cl1

V2 V1 V3

cl3

2

4

90

TCI

Cp50 Cp95 50% 95% Ausems

5

90

6 7 8

3 k

1e

k

eo

BDDF00069 4

5/56

Alaris™ PK Plus

TCI

k

eo

TCI

3

cl2

k

12

k

21

k

31

k

10

k

eo

k

13

cl1

V2 V1 V3

cl3

3-

TCI Alaris PK

Plus

TCI

TCI /

1. Danhof M: Does variability explain (all) variability in drug effects ?, Topics in pharmaceutical science.Edited by Breimer DD, Crommelin DJA, Midha KK.Noordwijk, Amsterdam

Med.Press BV, 1989, pp 573-586

2. Kruger-Theimer E: Continuous intravenous infusion and multicompartment accumulation.Eur J Pharmacol 1968; 4: 317-324

3. Schwilden H: A general method for calculating the dosage scheme in linear pharmacokinetics.Eur J Clin Pharmacol 1981; 20: 379-86

4. Shafer SL: Towards optimal intravenous dosing strategies.Seminars in Anesthesia 1993; 12: 222-234

5. Ausems ME, Hug CC, Jr., Stanski DR, Burm AG: Plasma concentrations of alfentanil required to supplement nitrous oxide anesthesia for general surgery.Anesthesiology 1986;

65: 362-73

6. Schnider TW, Minto CF, Stanski DR: The effect compartment concept in pharmacodynamic modelling.Anaesthetic Pharmacology Review 1994; 2: 204-213

7. Shafer SL: Principles of pharmacokinetics and pharmacodynamics., Principles and practice of anesthesiology.2nd Edition.Edited by Longnecker DE, Tinker JH, Morgan GE.New

York, Mosby-Year Book, 1998, pp 1159- 1210

8. Shafer SL, Gregg KM: Algorithms to rapidly achieve and maintain stable drug concentrations at the site of drug effect with a computer-controlled infusion pump.J

Pharmacokinet Biopharm 1992; 20: 147-69

TCI

Alaris PK Plus /

/

TCI

BDDF00069 4

6/56

Alaris™ PK Plus

TCI

Alaris PK Plus

Marsh

16

/

15 /

Vc = 0.228 x x

-1

)

k

10

= 0.119

-1

k

12

= 0.112

-1

k

13

= 0.0419

-1

k

21

= 0.055

-1

k

31

= 0.0033

-1

k

eo

= 0.26

-1

Marsh et al.: Brit J Anaesth 1991, 67, 41-48

Minto

12

/

20 /

Vc = 5.1 - 0.0201 x - 40+ 0.072 x (lbm - 55)

V2 = 9.82 - 0.0811 x - 40+ 0.108 x (lbm - 55)

V3 = 5.42

cl1 = 2.6 - 0.0162 x - 40+ 0.0191 x (lbm - 55)

cl2 = 2.05 - 0.0301 x - 40

cl3 = 0.076 - 0.00113 x - 40

k

10

= cl1 / Vc

k

12

= cl2 / Vc

k

13

= cl3 / Vc

k

21

= cl2 / V2

k

31

= cl3 / V3

k

eo

= 0.595 - 0.007 x - 40

Minto et al.: Anesthesiology 1997, 86, 10 - 33

Gepts

12

/

2 /

Vc = 14.3 l

k

10

= 0.0645

-1

k

12

= 0.1086

-1

k

13

= 0.0229

-1

k

21

= 0.0245

-1

k

31

= 0.0013

-1

Gepts et al.: Anesthesiology 1995, 83, 1194-1204

5.6 k

eo

k

eo

= 0.17559

-1

Shafer et al Anesthesiology.1991 Jan;74(1):53-63

BDDF00069 4

7/56

Alaris™ PK Plus

Alaris PK Plus

Alaris PK Editor (1000CH00016)

1. Alaris PK Editor

• * TIVA TCI

PK/PD

• Alaris PK

2. Alaris PK Editor

• *

• **

3. ALaris PK Editor

•

4. Alaris PK Plus Alaris PK Editor Transfer Tool

5.

• Alaris PK Plus CRC

Alaris PK Verification Tool

CRC

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6.

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BDDF00069 4

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BMI 21.6

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Alaris™ PK Plus

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BD Alaris

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MR

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MRI BD

MRI

(EMI)

(TSM)

BD

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EMC BD

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IEC/EN60601-1-2 IEC/EN60601-2-24

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BDDF00069 4

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Alaris™ PK Plus

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BDDF00069 4

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Alaris™ PK Plus

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Alaris™ PK Plus

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BDDF00069 4

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Alaris™ PK Plus

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BD Alaris™ PK Plus 注射泵 MK4 取扱説明書

BD Alaris™ PK Plus 注射泵 MK4 取扱説明書

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